Next-Generation Degraders & Glues on June 20-22, 2023 in London, United Kingdom

The 2nd Annual conference on Next-Generation Degraders & Glues brings together experts in the field to discuss the new therapeutic modalities detailed below, as well as issues underlying the use of targeted degradation as a new therapeutic approach.

The ubiquitin-proteasome, lysosome and autophagy systems are all well-controlled, selective degradation pathways that are key cellular regulators in cancer, CNS and other diseases. A new generation of hetero bi-functional chimeras and small molecule monovalent degraders are being developed to hijack these systems for targeted protein degradation or stabilization. These molecules that include Proteolysis-targeting chimeras (PROTACs) and molecular glues are being used to seek out previously “undruggable” targets for therapeutic intervention. However, challenges do exist in terms of specificity, stability, biodistribution and penetration of these degrader molecules.

Submit a speaker proposal, register, or become a sponsor!

Coverage will include, but is not limited to:

  • Update on emerging PROTACs, molecular glues, and new degrader modalities
  • Chasing new intracellular and extracellular drug targets
  • Design, characterization, and optimization of degraders and glues
  • Finding new E3 ligases for targeted degradation
  • New screening approaches to identify and optimize novel degraders
  • Tackling issues surrounding dosing, stability, biodistribution, tissue penetration, and more
  • Predicting and optimizing in vivo degrader specificity and safety

Name: Cambridge Innovation Institute
Address: 250 First Avenue, Suite 300 Needham, MA 02494

Description Price Date
Individual EUR 2599.00 Before June 22, 2023
Group EUR 1949.00 Before June 22, 2023
On-demand EUR 2199.00 Before June 22, 2023